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Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity (1).
Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Kreb’s cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health.
Additionally, Ca-AKG facilitates our internal recycling process known as autophagy, which removes dysfunctional cells, cell parts, and proteins from the body. Autophagy tends to decrease with age, so Ca-AKG may be able to help support this process.
Research has found that AKG lengthened lifespan in roundworms by up to 50% and delayed signs of aging (2). This may be because Ca-AKG activates AMP-activated protein kinase (AMPK) - a pathway that senses and maintains cellular energy balance by supporting the function of our cells’ main energy hubs (the mitochondria) and healthy blood sugar control (3).
Ca-AKG has also been shown to boost cellular antioxidant levels in aged mice, which helped support the mice’s blood vessel elasticity - a measure of good cardiovascular health (4).
- Suggested Daily Use: Take 2 capsules daily, in the morning, with or without food.
- Note: Store in a cool, dry place away from direct light. KEEP OUT OF REACH OF CHILDREN.
- Caution: If you are pregnant, nursing, have a medical condition or are taking prescription drugs, consult your health care professional before using this product.