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Additional Safety Highlights:
• Taking Niacin CRT™ at dinner time may help reduce the incidence and severity of flushing which may occur with high-dose niacin supplementation earlier in the day.
• Avoid taking with alcohol, hot beverages, or juice as this may accelerate the dissolution of the tablet, leading to higher initial levels of niacin into the bloodstream.
• Patients with a history of coronary insufficiency and those on vasodilating drugs should only use niacin under the guidance of a qualified health care provider given the potential for a hypotensive event.
• There are no known toxic metabolites of niacin, however, continued “amidation” associated with metabolizing nicotinates may result in liver stress. Therefore, less frequent dosing (and allowing 2-3 hours before dosing) may be recommended in order to clear the system (and therefore the liver) of the metabolizing nicotinates after seven to eight hours in order to reduce any potential increase in liver enzyme production.
• In addition, due to its fibrinolytic effect, niacin should be used with caution in conjunction with fibrinolytic and blood-thinning drugs.
• Taking niacin alone may raise homocysteine levels in some individuals.14
• It is recommended that any niacin formula be given with adequate amounts of B6, B12, and natural folates, and methionine, accomplished with the co-use of formulas such as B-Supreme, Twice Daily Multi™, Homocysteine Supreme™, or SAMe, to increase the efficiency of the liver during amidation.
• Others requiring increased caution include pregnant or nursing women, as well as patients with a known history of gallbladder disease, gout or acid-peptic disease.
As a dietary supplement, take one tablet per day with a meal, or as directed by your healthcare practitioner.