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Estrogen collectively refers to the female hormones estradiol, estrone and estriol. Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues). The most important message they deliver is to grow, divide, and multiply. For this reason, hormones are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance.
By keeping hormones in balance and ensuring the body is able to process hormones properly, cruciferous vegetable metabolites work together to reduce hormone overload and maintain cellular health. Current data on metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) suggests that these vegetable metabolites have strong potential for supporting breast, cervical, uterine and prostate health. I3C is a naturally occurring compound derived from cruciferous vegetables such as broccoli, Brussels sprouts and cabbage. With this in mind, EstroDIM includes targeted doses of both I3C and DIM in one capsule a day dosing to make daily balancing of hormones easy and convenient.
EstroDIM is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites I3C and DIM to support proper estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites that work together to support estrogen balance, breast and prostate health.
Indole-3-carbinol (I3C) is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors. A study published in the Journal of Nutrition unveiled evidence that I3C supports healthy cellular function related to estrogen metabolism.
Diindolylmethane (DIM) is a phytonutrient and plant indole also found in cruciferous vegetables with potential for enhancing proliferation of healthy cells and cellular activities. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhances the potential for greater antioxidant activity.
The body’s cells and organ systems depend on an adequate supply of energy to function optimally. The mitochondria, known as the power house of the cell, contain nutrients and enzymes that are important for cellular energy metabolism, including those that convert food to usable energy in the form of adenosine triphosphate (ATP). ATP functions as the key source of energy for all cells. In order to increase mitochondrial output, there must be adequate fuel supply for combustion and abundant antioxidants to scavenge free radical by-products. Preserving our energy reserves and increasing energy output is a critical part of maintaining optimal health.
There are many things that can drain energy reserves. Lack of sleep, too much stress, poor nutrition, and prescription medications can draw on our energy reserves using them up faster than they can be replenished. Even the vital biologic systems relied on to maintain health can create an energy deficit that needs to be restored.
MitoCORE is scientifically formulated, based on published research, to boost mitochondrial reserves and jump-start cellular energy production. MitoCORE includes the powerful antioxidant trio of alpha lipoic acid, N-acetyl cysteine and acetyl L-carnitine shown to increase energy production and at the same time, recharge the primary cellular antioxidant pools of vitamin E, C and glutathione. MitoCORE also includes key micronutrients and phytonutrients including green tea, broccoli seed extract and resveratrol to protect the mitochondria and continually renew the cycle of energy production.
Acetyl L-carnitine (ALC) is an amino acid that is associated with increased energy production. It has been shown to increase the flow of free fatty acids, the fuel source for mitochondria,resulting in a significant boost in energy production. As we age, free radical production increases oxidative damage to the mitochondria, which can potentially decrease energy production. ALC has been shown to increase cellular energy (ATP) production and has been found, in combination with lipoic acid, to lower oxidative stress. Studies have also shown that ALC supports the immune response by protecting CD4 and CD8 immune cells and by supporting the reproduction of lymphocytes for the identification and elimination of invading antigens.
N-acetyl cysteine (NAC) is an antioxidant that scavenges free radicals and promotes liver detoxification. NAC has been shown to increase production of glutathione, an important antioxidant found in the body. In addition to its antioxidant activity, glutathione boosts the immune system by activating T-cells, helping to maintain immune balance.
Alpha Lipoic Acid
Alpha lipoic acid (ALA) is a potent antioxidant and also plays a synergistic role in recharging other antioxidants such as vitamin C, vitamin E, CoQ10 and glutathione. Lipoic acid also plays a key role in detoxification. Studies have shown that a combination of ALA and acetyl L-carnitine helps minimize oxidative damage. Oxidative stress causes damage to DNA, RNA, proteins, mitochondrial membranes, and lipids and contributes to the functional decline of mitochondria, cells,tissues, and eventually organs such as the brain.
Resveratrol is a polyphenol molecule found in many plant species including grapes and cranberries and is found in high concentrations in wine. Polyphenols act as antioxidants that protect plants from damage that can be caused by bacteria, fungi, and radiation. Resveratrol is believed to be the dietary factor behind the “French Paradox” which is the high rate of cardiovascular wellness in the French population, despite their high fat intake. In addition to its antioxidant properties and support for cardiovascular function, resveratrol has been shown to support optimal immune function.
SGS™ Broccoli Seed Extract
Broccoli seed extract contains a high amount of glucoraphanin, a compound that is a precursorto sulphoraphane. Sulphoraphane is a potent antioxidant in the body and also supports detoxification and immune response. Sulphoraphane has been shown to induce Phase II detoxification enzymes and raise intracellular glutathione levels.
Green Tea (EGCG)
Green tea polyphenols have demonstrated significant antioxidant, probiotic and immune supporting properties. The hydroxyl group of green tea polyphenols supports antioxidant activity by forming complexes with free radicals and neutralizing them, minimizing oxidative damage throughout the body. Green tea polyphenols also stimulate the activity of liver detoxification enzymes, promoting the detoxification of harmful chemicals out of the body.
To increase cellular energy production efficiently, optimal levels of critical nutrients and enzyme cofactors must be achieved. MitoCORE is a multivitamin with an optimized backbone of vitamins and minerals necessary for increasing energy output and meeting daily nutritional needs.
A wide and complex variety of B vitamins is essential for the body to convert food into cellular energy. These water-soluble groups of vitamins are first absorbed in the small intestine and then travel to the liver where they are biotransformed into their active coenzyme forms. One of the key roles of B vitamins is to serve as prime coenzymes for the Kreb’s cycle, the biochemical pathway responsible for maintaining energy production. In addition, B vitamins, particularly folate, B6 and B12, are critical for proper methylation, a biochemical process that helps convert the problematic amino acid metabolite homocysteine into the amino acids methionine and cysteine. This process is vital for supporting cardiovascular and mental health, a healthy nervous system, regulating gene expression, proper energy metabolism, as well as immune and nerve cell function. Additional intake of B vitamins is often needed by individuals with high levels of stress.
Methyl B Complex is a balanced and comprehensive supplement that includes eight essential B vitamins, along with choline, inositol and folate as Quatrefolic® -100% 5-MTHF. The high-quality ingredients included in Methyl B Complex help build a healthy micronutrient reserve to support energy production in the body.
Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is found naturally in foods such as fruits and dark leafy vegetables, but can be easily destroyed by cooking or processing. Additionally, enzyme defects, malabsorption and congenital deficiency of 5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme required for the conversion of folic acid to its bioactive form 5-methyltetrahydrofolate (5-MTHF), can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF has been shown to be beneficial. 5-MTHF is required as a methyl group donor for the production of mood regulating neurotransmitters such as serotonin, the synthesis of melatonin, as well as DNA production and repair.
Thiamine (Vitamin B1)
While naturally abundant in whole grains, thiamine is lost in many of the over-processed grains commonly consumed today. Thiamine is an essential co-factor in the production of ATP in the cells’ Kreb's cycle, and is also needed for the metabolism of fats, proteins and carbohydrates.
Riboflavin (Vitamin B2)
Riboflavin is a precursor to flavin adenine dinucleodtide (FAD) and flavin mononucleotide (FMN), both of which are central to energy production, intermediary metabolism, and act as powerful antioxidants. Riboflavin-depleted cells have been found to display signs of greater oxidative stress and disrupted energy generation.
Niacin is a cofactor in the mitochondrial respiratory chain, which produces cellular energy. In the body, niacin is transformed into NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which both play a role in oxidation reduction reactions in cells.
Vitamin B6 is involved in over 100 enzymatic reactions in the body and is essential for gluconeogenesis, lipid metabolism, neurotransmitter formation, immune health and hormone modulation, and is essential in methylation, for the breakdown of homocysteine.
Vitamin B12 (Methylcobalamin)
Vitamin B12, found only in organ meats, seafood and egg yolks, often becomes deficient in vegan and vegetarian diets. The vitamin is essential for the metabolism of fats and carbohydrates, the synthesis of proteins, and also plays a role in regulating mitochondrial enzymes and energy metabolism, as well as neurological health.
Synthesized by the bacteria in the gut and in certain foods, biotin and its cofactors are involved in metabolism of fatty acids, amino acids and the utilization of B vitamins.
Pantothenic acid and its biologically active derivative, CoA, are essential to the synthesis of fatty acids, membrane phospholipids, amino acids, steroid hormones, and energy production.
Though not technically a B vitamin, choline is often associated with the B vitamin complex. It is important in the construction of cell membranes and plasma lipoproteins, plays a role in cell signaling and in the synthesis of acetylcholine (a neurotransmitter), and is vital for brain development.