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Boston Heart Thyroid Stimulating Hormone (TSH) Test

Boston HeartSKU: AFH-BH1005-I4-ICD
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Methodology

Immunoassay

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

None

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 14 days

Full Description

Thyroid Stimulating Hormone (TSH)

  • Low:  <0.27 µlU/mL
  • Optimal: 0.27-4.20 µlU/mL
  • High:  >4.20 µlU/mL
  • TSH is used in the differential diagnosis of primary, secondary, & tertiary hypothyroidism.1-3
  • Is also useful in screening for hyperthyroidism.1-3
  • Allows adjustment of thyroid replacement in hypothyroid patients.1-3
  • High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.

References:

  1. Goodman N, Cobin RH. Reproductive disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:190-228.
  2. Castro MR, Gharib H. Thyroid disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:43-80.
  3. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028.
  • Low value is consistent with either an overactive thyroid gland or excess thyroid hormone replacement. Additional diagnostic testing such as Free T4 and/or Total T3 as required.
  • High value is consistent with an underactive thyroid gland or inadequate thyroid hormone replacement. Additional diagnostic testing such as Free T4 and/or Total T3 as required.
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