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Toxic and Essential Elements - Fecal Metals

Doctors DataSKU: A2803

Fecal elemental analysis provides a direct indication of dietary exposure to toxic metals and indirect information about the potential for toxic metal burden. Chronic, low-level assimilation of toxic metals can result in accumulation in the body. For many toxic metals, fecal (biliary) excretion is the primary natural route of elimination from the body. Specimen collection is convenient for the patient...

Full Description

This test is useful for

  • Dietary Exposure to Toxic Elements
  • Mercury Exposure from Dental Amalgams

For More Detail:

Please contact us at (714) 864-3730 or to order your test.

Toxic and Essential Elements

Elements are the basic building blocks of all chemical compounds, and human exposure to them occurs both from natural and anthropogenic sources. Many elements are considered nutrients and are essential for the proper functioning of the body. These are generally divided between macrominerals such as calcium, magnesium, potassium, sodium and zinc, and trace minerals including selenium, iodine, boron and molybdenum.

Conversely, there are a number of elements that are toxic to the human body, interfere with its functioning and undermine health—such as mercury, lead, cadmium, aluminum, and arsenic. These toxic metals have no known physiological functions. They can be toxic to organ systems and may disrupt the balance of essential nutrients. Toxic metals and essential element status can be assessed in urine, blood, feces and hair.

Doctor's Data has always employed the best-available techniques as a specialist and pioneer in essential and toxic elemental testing. In fact, we were one of the first clinical reference laboratories in the world to employ ICP-MS and high-resolution ICP-MS for elemental analysis.

Detailed Information

Analysis of elements in feces provides a comprehensive evaluation of environmental exposure, potential for accumulation in the body (Hg), and possibly endogenous detoxification of potentially toxic metals. For many toxic elements such as mercury, cadmium, lead, antimony and uranium, biliary excretion into the feces is the primary natural route of elimination from the body. The primary process by which the body eliminates the insidious sulfhydryl reactive metals is through the formation of metal-glutathione complexes, of which greater than 90% are excreted into the bile. Evidence for the extent of exposure to mercury from dental amalgams is provided by the fact that fecal mercury levels are highly correlated with the number of amalgams in the mouth. It also clear that fecal mercury levels for people with dental amalgams are remarkably similar from day to day, and approximately ten times higher than in people who do not have mercury amalgams. Administration of pharmaceutical metal binding agents results in excretion of toxic metals primarily through the kidneys into the urine. In contrast, support of natural detoxification processes enhances the rate of excretion of toxic metals into the feces. Elemental analysis of fecal specimens can provide a valuable tool to monitor the efficacy of natural detoxification of metals in infants or patients who are on very limited and defined diets that do not contain contaminated solid foods. A preliminary study performed at Doctor's Data indicates that biliary/fecal excretion of mercury and lead may be markedly enhanced following high-dose intravenous administration of ascorbic acid. Other orthomolecular or nutraceutical protocols may also enhance the fecal excretion of metals and hence potentially decrease burden on the kidneys. Further research to identify and validate such therapies is warranted. A primary objective of preventive medicine is avoidance or removal of exposure to toxic substances. The rate of oral absorption of toxic metals varies considerably among elements, and among subspecies of a particular element. Fecal elemental analysis can provide a direct indication of dietary exposure. Orally, the percent absorption of nickel, cadmium and lead is usually quite low, but varies significantly in part due to the relative abundance of antagonistic essential elements in the diet. That is particularly evident for lead and calcium, and cadmium and zinc. Chronic, low-level assimilation of the toxic metals can result in significant accumulation in the body. The results of fecal elemental analysis can help identify and eliminate dietary exposure to toxic metals. The fecal metals test was not developed to replace the pre- and post-urinary toxic metals provocation test, but rather provides an alternative for infants, children or adults for whom urine collection is problematic, or for individuals who do not tolerate the available pharmaceutical metal detoxification agents. Elements are measured by ICP-MS and expressed on a dry weight basis to eliminate variability related to water content of the specimen.

Usage Directions

Before You Start:

Please read all of the directions, and familiarize yourself with the collection procedures. There are no special dietary restrictions. Don’t collect your specimen within 3 days of having a GI exam using barium contrast agents or having dental amalgams (silver fillings) installed or removed. Never discontinue prescription medications without first consulting your physician.

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